InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nr0b2

Summary

InnateDB Protein

IDBP-195191.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nr0b2

Protein Name

nuclear receptor subfamily 0, group B, member 2

Synonyms

SHP; SHP-1; Shp1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039175

InnateDB Gene

IDBG-195189 (Nr0b2)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1. {ECO:0000269PubMed:8650544}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus. Note=Colocalizes with NEUROD1 in the nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in islets of Langerhans (at protein level). {ECO:0000269PubMed:14752053}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	55 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019904	protein domain specific binding
GO:0032403	protein complex binding
GO:0042803	protein homodimerization activity
GO:0042974	retinoic acid receptor binding
GO:0042975	peroxisome proliferator activated receptor binding
GO:0046965	retinoid X receptor binding
GO:0046966	thyroid hormone receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0009749	response to glucose
GO:0031100	organ regeneration
GO:0032024	positive regulation of insulin secretion
GO:0043401	steroid hormone mediated signaling pathway
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892	negative regulation of transcription, DNA-templated