InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dnajc24

Summary

InnateDB Protein

IDBP-195273.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dnajc24

Protein Name

DnaJ (Hsp40) homolog, subfamily C, member 24

Synonyms

1700030A21Rik; 2610027M02Rik; AV066965; AW240712; Dph4; MmDjC7; Zcsl3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099615

InnateDB Gene

IDBG-195271 (Dnajc24)

Protein Structure

UniProt Annotation

Function

The iron-bound form is redox-active and can function as electron carrier (By similarity). Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). {ECO:0000250, ECO:0000269PubMed:11595173, ECO:0000269PubMed:18765564}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:18765564}.

Disease Associations

Tissue Specificity

Detected in heart, brain, spleen, lung, liver, kidney and testis. {ECO:0000269PubMed:11595173}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001671	ATPase activator activity
GO:0008198	ferrous iron binding
GO:0008270	zinc ion binding

Biological Process

GO:0017183	peptidyl-diphthamide biosynthetic process from peptidyl-histidine
GO:0032781	positive regulation of ATPase activity
GO:0055114	oxidation-reduction process