InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptpro

Summary

InnateDB Protein

IDBP-195287.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptpro

Protein Name

protein tyrosine phosphatase, receptor type, O

Synonyms

D28; GLEPP1; PTPBK; Ptpn15; PTPoc; PTPphi; PTPROt; PTPU2; R-PTP-O;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000076364

InnateDB Gene

IDBG-195285 (Ptpro)

Protein Structure

UniProt Annotation

Function

Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function. {ECO:0000269PubMed:11086029}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0017147	Wnt-protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000902	cell morphogenesis
GO:0002548	monocyte chemotaxis
GO:0003093	regulation of glomerular filtration
GO:0003105	negative regulation of glomerular filtration
GO:0006470	protein dephosphorylation
GO:0007411	axon guidance
GO:0016311	dephosphorylation
GO:0030032	lamellipodium assembly
GO:0032835	glomerulus development
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0036060	slit diaphragm assembly
GO:0072112	glomerular visceral epithelial cell differentiation
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0016328	lateral plasma membrane
GO:0043197	dendritic spine
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1097152

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR003961 Fibronectin, type III
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00041
PF01108

PRINTS

PR00700

PIRSF

SMART

SM00194
SM00404
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt