Version 5.4
Homo sapiens Protein: IQSEC1
Summary
InnateDB Protein IDBP-19529.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IQSEC1
Protein Name IQ motif and Sec7 domain 1
Synonyms ARF-GEP100; ARFGEP100; BRAG2; GEP100;
Species Homo sapiens
Ensembl Protein ENSP00000273221
InnateDB Gene IDBG-19527 (IQSEC1)
Protein Structure
UniProt Annotation
Function In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin. {ECO:0000269PubMed:11226253, ECO:0000269PubMed:16461286}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:11226253}. Nucleus {ECO:0000269PubMed:11226253}. Note=At steady state, may be preferentially cytosolic.
Disease Associations
Tissue Specificity Expressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis. {ECO:0000269PubMed:11226253, ECO:0000269PubMed:9872452}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0030036 actin cytoskeleton organization
GO:0032012 regulation of ARF protein signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005730 nucleolus
GO:0016020 membrane
GO:0030054 cell junction
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR000048 IQ motif, EF-hand binding site
IPR000904 Sec7 domain
IPR001849 Pleckstrin homology domain
PFAM PF00612
PF01369
PF00169
PRINTS
PIRSF
SMART SM00015
SM00222
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6DN90
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 9922
UniGene Hs.607511
RefSeq NP_055684
HUGO HGNC:29112
OMIM 610166
CCDS CCDS33703
HPRD 11052
IMGT
EMBL AB018306 AY653734 BC010267
GenPept AAH10267 AAT72063 BAA34483

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca