InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mlycd

Summary

InnateDB Protein

IDBP-195321.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mlycd

Protein Name

malonyl-CoA decarboxylase

Synonyms

AI324784; Mcd;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095970

InnateDB Gene

IDBG-195319 (Mlycd)

Protein Structure

UniProt Annotation

Function

Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. Plays a role in controlling the extent of ischemic injury by promoting glucose oxidation. {ECO:0000269PubMed:17030679, ECO:0000269PubMed:23746352}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Mitochondrion matrix {ECO:0000269PubMed:23746352}. Peroxisome {ECO:0000250}. Peroxisome matrix {ECO:0000250}. Note=Enzymatically active in all three subcellular compartments. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0050080	malonyl-CoA decarboxylase activity

Biological Process

GO:0002931	response to ischemia
GO:0006085	acetyl-CoA biosynthetic process
GO:0006633	fatty acid biosynthetic process
GO:0010906	regulation of glucose metabolic process
GO:0019395	fatty acid oxidation
GO:0031998	regulation of fatty acid beta-oxidation
GO:0046320	regulation of fatty acid oxidation
GO:0046321	positive regulation of fatty acid oxidation
GO:2001294	malonyl-CoA catabolic process