InnateDB Protein
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IDBP-195357.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Wash
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Protein Name
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open reading frame 19
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Synonyms
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1110049F14Rik; ORF19; Wash1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000072220
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InnateDB Gene
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IDBG-195355 (Wash)
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Protein Structure
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Function |
Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000269PubMed:19922875}.
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Subcellular Localization |
Early endosome membrane {ECO:0000269PubMed:19922875}. Recycling endosome membrane {ECO:0000269PubMed:19922875}. Note=Localization to the endodome membrane is mediated via its interaction with FAM21.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. {ECO:0000269PubMed:19922875}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
1
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1916017
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InterPro |
IPR003124
WH2 domain
IPR021854
WASH1, WAHD domain
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PFAM |
PF02205
PF11945
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PRINTS |
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PIRSF |
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SMART |
SM00246
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TIGRFAMs |
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Modification |
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SwissProt |
Q8VDD8
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PhosphoSite |
PhosphoSite-Q8VDD8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
68767
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UniGene |
Mm.296545
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RefSeq |
NP_081109
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MGI ID |
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MGI Symbol |
Wash
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OMIM |
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CCDS |
CCDS28944
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HPRD |
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IMGT |
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EMBL |
AJ304796
AK033616
AK149967
AK154400
AK159820
AK171737
AK172673
BC025839
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GenPept |
AAH25839
BAC28393
BAE29201
BAE32561
BAE35400
BAE42641
BAE43124
CAC83096
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