Version 5.4
Mus musculus Protein: Fshb
Summary
InnateDB Protein IDBP-195411.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fshb
Protein Name follicle stimulating hormone beta
Synonyms FSH; Fshbeta;
Species Mus musculus
Ensembl Protein ENSMUSP00000028533
InnateDB Gene IDBG-195409 (Fshb)
Protein Structure
UniProt Annotation
Function Stimulates development of follicle and spermatogenesis in the reproductive organs.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 0
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0005515 protein binding
Biological Process
GO:0001541 ovarian follicle development
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0042699 follicle-stimulating hormone signaling pathway
GO:0045670 regulation of osteoclast differentiation
GO:0045780 positive regulation of bone resorption
GO:0060011 Sertoli cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:95582
InterPro IPR001545 Gonadotropin, beta subunit
IPR006208 Glycoprotein hormone subunit beta, cystine knot
IPR029034 Cystine-knot cytokine
PFAM PF00007
PRINTS
PIRSF
SMART SM00068
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q60687
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 14308
UniGene Mm.402121
RefSeq NP_032071
MGI ID
MGI Symbol Fshb
OMIM
CCDS CCDS16504
HPRD
IMGT
EMBL AK017593 BC061159 U12932
GenPept AAA92804 AAH61159 BAB30827

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca