InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCNK

Summary

InnateDB Protein

IDBP-19549.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCNK

Protein Name

cyclin K

Synonyms

CPR4;

Species

Homo sapiens

Ensembl Protein

ENSP00000374529

InnateDB Gene

IDBG-19541 (CCNK)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). {ECO:0000269PubMed:10574912, ECO:0000269PubMed:22012619, ECO:0000269PubMed:9632813}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:22012619}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Highest levels in testis. {ECO:0000269PubMed:9632813}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0001701	in utero embryonic development
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0007067	mitotic nuclear division
GO:0071157	negative regulation of cell cycle arrest