InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rbm19

Summary

InnateDB Protein

IDBP-195492.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rbm19

Protein Name

RNA binding motif protein 19

Synonyms

1200009A02Rik; AV302714; NPO;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031590

InnateDB Gene

IDBG-195490 (Rbm19)

Protein Structure

UniProt Annotation

Function

Plays a role in embryo pre-implantation development. {ECO:0000269PubMed:19087264}.

Subcellular Localization

Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm. Chromosome. Note=Colocalizes with NPM1 during interphase. By late prophase, metaphase, anaphase and telophase, associates with the chromosome periphery. By telophase localizes to nucleolar precursor body (NPB) (By similarity). In discrete foci distributed throughout the cytoplasm and nucleoplasm during the 4 to 8 cell stages and the morula stage, but not in the periphery of the NPB. During blastocyst development, becomes increasingly localized to the nucleolus and less to the cytoplasm. At the late blastocyst stage, localized predominantly in the nucleolus. Localized in the nucleolus during interphase and to the perichromosomal sheath during mitosis. Does not colocalize in the cytoplasm with GW182 in P-bodies. May translocate to the nucleolus upon early embryonic development. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the crypts of Lieberkuhn of the intestine (at protein level). {ECO:0000269PubMed:16027046}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.