Version 5.4
| Mus musculus Protein: Manba | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-195547.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Manba | ||||||||
| Protein Name | mannosidase, beta A, lysosomal | ||||||||
| Synonyms | 2410030O07Rik; B930014J03Rik; Bmn; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000029814 | ||||||||
| InnateDB Gene | IDBG-195545 (Manba) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides. {ECO:0000250UniProtKB:O00462}. | ||||||||
| Subcellular Localization | Lysosome {ECO:0000250UniProtKB:O00462}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Highest level in liver, high levels in lung, testis, skin and spleen, moderate level in thymus. Activity found in plasma, kidney, liver, spleen, pancreas, brain, testis, epididymis, heart, lung and skeletal muscle. {ECO:0000269PubMed:11892998, ECO:0000269PubMed:16377659}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:88175 | ||||||||
| InterPro |
IPR006102
Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich IPR006103 Glycoside hydrolase, family 2, TIM barrel IPR006104 Glycosyl hydrolases family 2, sugar binding domain IPR008979 Galactose-binding domain-like IPR017853 Glycoside hydrolase, superfamily |
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| PFAM |
PF00703
PF02836 PF02837 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q8K2I4 | ||||||||
| PhosphoSite | PhosphoSite-Q8K2I4 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 110173 | ||||||||
| UniGene | Mm.408585 | ||||||||
| RefSeq | NP_081564 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Manba | ||||||||
| OMIM | |||||||||
| CCDS | CCDS17857 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AF306557 AK010623 AK142165 AK166340 AK170290 BC031409 | ||||||||
| GenPept | AAH31409 AAK18177 BAB27069 BAE24954 BAE38715 BAE41690 | ||||||||