InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bbox1

Summary

InnateDB Protein

IDBP-195647.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bbox1

Protein Name

butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046302

InnateDB Gene

IDBG-195645 (Bbox1)

Protein Structure

UniProt Annotation

Function

Catalyzes the formation of L-carnitine from gamma- butyrobetaine. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008270	zinc ion binding
GO:0008336	gamma-butyrobetaine dioxygenase activity
GO:0016491	oxidoreductase activity
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

Biological Process

GO:0045329	carnitine biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0015629	actin cytoskeleton
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1891372

InterPro

IPR003819 Taurine catabolism dioxygenase TauD/TfdA
IPR010376 Domain of unknown function, DUF971
IPR012775 Gamma-butyrobetaine,2-oxoglutarate dioxygenase

PFAM

PF02668
PF06155

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q924Y0

PhosphoSite