Version 5.4
Mus musculus Protein: Wdr82
Summary
InnateDB Protein IDBP-195670.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wdr82
Protein Name WD repeat domain containing 82
Synonyms 9430077D24Rik; CDW5/WDR82;
Species Mus musculus
Ensembl Protein ENSMUSP00000020490
InnateDB Gene IDBG-195668 (Wdr82)
Protein Structure
UniProt Annotation
Function Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Possible role in telomere length maintenance and in mRNA processing (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Note=Associates with chromatin. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0042800 histone methyltransferase activity (H3-K4 specific)
Biological Process
GO:0051568 histone H3-K4 methylation
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0035097 histone methyltransferase complex
GO:0048188 Set1C/COMPASS complex
GO:0072357 PTW/PP1 phosphatase complex
Protein Structure and Domains
PDB ID MGI:1924555
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
PFAM PF00400
PRINTS PR00320
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BFQ4
PhosphoSite PhosphoSite-Q8BFQ4
TrEMBL B2RXQ8
UniProt Splice Variant
Entrez Gene 77305
UniGene Mm.265125
RefSeq NP_084172
MGI ID
MGI Symbol Wdr82
OMIM
CCDS CCDS40754
HPRD
IMGT
EMBL AK035109 AK037620 AK149692 BC019115 BC031502 BC157943 BC157945 BC158054 CH466560 EF011615
GenPept AAH19115 AAH31502 AAI57944 AAI57946 AAI58055 ABK41105 BAC28947 BAC29836 BAE29029 EDL21119 EDL21120

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca