InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Twf2

Summary

InnateDB Protein

IDBP-195781.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Twf2

Protein Name

twinfilin, actin-binding protein, homolog 2 (Drosophila)

Synonyms

A6-related; AU014993; Ptk9l; Ptk9r;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024047

InnateDB Gene

IDBG-195779 (Twf2)

Protein Structure

UniProt Annotation

Function

Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia. {ECO:0000269PubMed:18837697, ECO:0000269PubMed:19955359}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell projection, stereocilium. Note=Perinuclear and G-actin-rich cortical actin structure sublocalization. Isoform 2 found also along myofibrils in cardiomyocytes. Localized in cochlea hair cells to the tips of the middle and short rows of stereocilia.

Disease Associations

Tissue Specificity

Isoform 1 is ubiquitously expressed (at protein level). Isoform 2 expression is restricted to heart and skeletal muscle where it is the predominant form. {ECO:0000269PubMed:10406962, ECO:0000269PubMed:18837697}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0003785	actin monomer binding
GO:0005080	protein kinase C binding
GO:0005524	ATP binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0010592	positive regulation of lamellipodium assembly
GO:0010976	positive regulation of neuron projection development
GO:0030030	cell projection organization
GO:0030837	negative regulation of actin filament polymerization
GO:0032532	regulation of microvillus length
GO:0032956	regulation of actin cytoskeleton organization
GO:0035556	intracellular signal transduction
GO:0042989	sequestering of actin monomers
GO:0045773	positive regulation of axon extension
GO:0051016	barbed-end actin filament capping
GO:0071300	cellular response to retinoic acid
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0030016	myofibril
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0030426	growth cone
GO:0032420	stereocilium
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome