InnateDB Protein
|
IDBP-19592.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
TAS2R13
|
Protein Name
|
taste receptor, type 2, member 13
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000375095
|
InnateDB Gene
|
IDBG-19590 (TAS2R13)
|
Protein Structure
|
|
Function |
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.
|
Subcellular Localization |
Membrane; Multi-pass membrane protein.
|
Disease Associations |
|
Tissue Specificity |
Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
GO:0001580
|
detection of chemical stimulus involved in sensory perception of bitter taste
|
GO:0007186
|
G-protein coupled receptor signaling pathway
|
GO:0032467
|
positive regulation of cytokinesis
|
GO:0050909
|
sensory perception of taste
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR007960
Mammalian taste receptor
|
PFAM |
PF05296
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9NYV9
|
PhosphoSite |
PhosphoSite-Q9NYV9
|
TrEMBL |
Q50KQ5
|
UniProt Splice Variant |
|
Entrez Gene |
50838
|
UniGene |
Hs.679407
|
RefSeq |
NP_076409
|
HUGO |
HGNC:14919
|
OMIM |
604792
|
CCDS |
CCDS8635
|
HPRD |
11991
|
IMGT |
|
EMBL |
AB199108
AF227137
AY724945
BC069376
BC095518
|
GenPept |
AAF43910
AAH69376
AAH95518
AAU21147
BAD97993
|
|
|