Version 5.4
Mus musculus Protein: Zfp593
Summary
InnateDB Protein IDBP-196052.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Zfp593
Protein Name zinc finger protein 593
Synonyms 3110024A21Rik; AV062409; E130106C14Rik; ZNF593;
Species Mus musculus
Ensembl Protein ENSMUSP00000030644
InnateDB Gene IDBG-196050 (Zfp593)
Protein Structure
UniProt Annotation
Function Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleolus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008150 biological_process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
Protein Structure and Domains
PDB ID MGI:1915290
InterPro IPR003604 Zinc finger, U1-type
IPR007087 Zinc finger, C2H2
IPR022755 Zinc finger, double-stranded RNA binding
PFAM PF00096
PF12171
PRINTS
PIRSF
SMART SM00451
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DB42
PhosphoSite PhosphoSite-Q9DB42
TrEMBL
UniProt Splice Variant
Entrez Gene 68040
UniGene Mm.300404
RefSeq NP_077177
MGI ID
MGI Symbol Zfp593
OMIM
CCDS CCDS51325
HPRD
IMGT
EMBL AK005247 AK133585 AL627314 BC003465
GenPept AAH03465 BAB23902 BAE21733 CAM21943

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca