InnateDB Protein
|
IDBP-196206.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Zdhhc7
|
Protein Name
|
zinc finger, DHHC domain containing 7
|
Synonyms
|
AL024087; Gramp2;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000034280
|
InnateDB Gene
|
IDBG-196204 (Zdhhc7)
|
Protein Structure
|
|
Function |
Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptors (By similarity). Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and regulate their synaptic clustering and/or cell surface stability. {ECO:0000250, ECO:0000269PubMed:15229235, ECO:0000269PubMed:15603741}.
|
Subcellular Localization |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Ubiquitously expressed, with highest levels in liver, kidney and brain. Expressed in all brain regions. {ECO:0000269PubMed:15603741}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
3 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:2142662
|
InterPro |
IPR001594
Zinc finger, DHHC-type, palmitoyltransferase
|
PFAM |
PF01529
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q91WU6
|
PhosphoSite |
PhosphoSite-Q91WU6
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
102193
|
UniGene |
|
RefSeq |
NP_598728
|
MGI ID |
|
MGI Symbol |
Zdhhc7
|
OMIM |
|
CCDS |
CCDS22715
|
HPRD |
|
IMGT |
|
EMBL |
AK041905
AK157968
AK170639
AK170923
AK172462
AY166673
BC013467
BC029666
BC075666
|
GenPept |
AAH13467
AAH29666
AAH75666
AAO27360
BAC31093
BAE34289
BAE41929
BAE42116
BAE43018
|
|
|