Version 5.4
Mus musculus Protein: Pde3a
Summary
InnateDB Protein IDBP-196290.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pde3a
Protein Name phosphodiesterase 3A, cGMP inhibited
Synonyms A930022O17Rik; C87899;
Species Mus musculus
Ensembl Protein ENSMUSP00000038749
InnateDB Gene IDBG-196288 (Pde3a)
Protein Structure
UniProt Annotation
Function Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Involved in oocyte maturation. {ECO:0000269PubMed:11420239}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
GO:0030552 cAMP binding
GO:0046872 metal ion binding
Biological Process
GO:0001556 oocyte maturation
GO:0006198 cAMP catabolic process
GO:0007165 signal transduction
GO:0016101 diterpenoid metabolic process
GO:0019933 cAMP-mediated signaling
GO:0019934 cGMP-mediated signaling
GO:0040020 regulation of meiosis
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043116 negative regulation of vascular permeability
GO:0043117 positive regulation of vascular permeability
GO:0051591 response to cAMP
GO:0060282 positive regulation of oocyte development
GO:0071321 cellular response to cGMP
GO:0071560 cellular response to transforming growth factor beta stimulus
Cellular Component
GO:0005829 cytosol
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1860764
InterPro IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
PFAM PF00233
PRINTS
PIRSF
SMART SM00471
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z0X4
PhosphoSite PhosphoSite-Q9Z0X4
TrEMBL B2RR84
UniProt Splice Variant
Entrez Gene 54611
UniGene
RefSeq NP_061249
MGI ID
MGI Symbol Pde3a
OMIM
CCDS CCDS20676
HPRD
IMGT
EMBL AF099187 BC138265 BC138266 CH466572
GenPept AAD16300 AAI38266 AAI38267 EDL10621

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca