InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GSX1

Summary

InnateDB Protein

IDBP-19631.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSX1

Protein Name

GS homeobox 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000304331

InnateDB Gene

IDBG-19629 (GSX1)

Protein Structure

UniProt Annotation

Function

Probable transcription factor that binds to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'. Activates the transcription of the GHRH gene. Plays an important role in pituitary development.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0021527	spinal cord association neuron differentiation
GO:0021854	hypothalamus development
GO:0021984	adenohypophysis development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048663	neuron fate commitment