InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slco1c1

Summary

InnateDB Protein

IDBP-196372.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slco1c1

Protein Name

solute carrier organic anion transporter family, member 1c1

Synonyms

OATP-14; OATP-F; Oatp2; Oatpf; Slc21a14;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032362

InnateDB Gene

IDBG-196370 (Slco1c1)

Protein Structure

UniProt Annotation

Function

Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), estradiol-17-beta-glucuronide, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency (By similarity). May play a signifiant role in regulating T4 flux into and out of the brain (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:18687783}; Multi-pass membrane protein {ECO:0000269PubMed:18687783}.

Disease Associations

Tissue Specificity

Highly expressed in cerebral microvessels (at protein level). Highly expressed in cerebral microvessels throughout the brain and in tanycytes of the third ventricle. {ECO:0000269PubMed:18687783}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1889679

InterPro

IPR002350 Kazal domain
IPR004156 Organic anion transporter polypeptide OATP
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00050
PF07648
PF03137
PF07690

PRINTS

PIRSF

SMART

SM00280

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9ERB5