Version 5.4
Mus musculus Protein: Txndc17
Summary
InnateDB Protein IDBP-196375.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Txndc17
Protein Name thioredoxin domain containing 17
Synonyms 4831443O22Rik; D11Ertd672e; TRP14; Txnl5;
Species Mus musculus
Ensembl Protein ENSMUSP00000021158
InnateDB Gene IDBG-196373 (Txndc17)
Protein Structure
UniProt Annotation
Function Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004601 peroxidase activity
GO:0005515 protein binding
GO:0009055 electron carrier activity
GO:0047134 protein-disulfide reductase activity
Biological Process
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1289248
InterPro IPR010357 Protein of unknown function DUF953, thioredoxin-like
IPR012336 Thioredoxin-like fold
PFAM PF06110
PF13098
PF13192
PF13462
PF13905
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CQM5
PhosphoSite PhosphoSite-Q9CQM5
TrEMBL
UniProt Splice Variant
Entrez Gene 52700
UniGene Mm.27670
RefSeq NP_080835
MGI ID 1V9W
MGI Symbol Txndc17
OMIM
CCDS CCDS24980
HPRD
IMGT
EMBL AJ344103 AK004219 AK007595 AK013103 AK076425 AK169882 BC030344 BX119911
GenPept AAH30344 BAB23225 BAB25126 BAB28648 BAC36336 BAE41434 CAC51438 CAI24478

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca