InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slco1b2

Summary

InnateDB Protein

IDBP-196446.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slco1b2

Protein Name

solute carrier organic anion transporter family, member 1b2

Synonyms

7330442B20Rik; lst-1; mlst-1; OATP-C; Oatp1b2; OATP2; Oatp4; Slc21a10; Slc21a6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044326

InnateDB Gene

IDBG-196444 (Slco1b2)

Protein Structure

UniProt Annotation

Function

Mediates the Na(+)-independent uptake of organic anions such as taurochlate, bromosulfophthalein and steroid conjugates such as estrone-3-sulfate, 17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate and prostaglandin E2. {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Liver specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0008514	organic anion transmembrane transporter activity
GO:0015125	bile acid transmembrane transporter activity
GO:0015198	oligopeptide transporter activity
GO:0015238	drug transmembrane transporter activity

Biological Process

GO:0001889	liver development
GO:0006810	transport
GO:0006855	drug transmembrane transport
GO:0006857	oligopeptide transport
GO:0015721	bile acid and bile salt transport
GO:0015893	drug transport
GO:0032496	response to lipopolysaccharide
GO:0033993	response to lipid
GO:0034097	response to cytokine
GO:0042493	response to drug
GO:0043434	response to peptide hormone
GO:0046677	response to antibiotic
GO:0051384	response to glucocorticoid
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane

Protein Structure and Domains

PDB ID

MGI:1351899

InterPro

IPR002350 Kazal domain
IPR004156 Organic anion transporter polypeptide OATP
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00050
PF07648
PF03137
PF07690

PRINTS

PIRSF

SMART

SM00280

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JJL3