InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptges3

Summary

InnateDB Protein

IDBP-196478.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptges3

Protein Name

prostaglandin E synthase 3 (cytosolic)

Synonyms

5730442A20Rik; cPGES; p23; Ptges; sid3177; Tebp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050292

InnateDB Gene

IDBG-196476 (Ptges3)

Protein Structure

UniProt Annotation

Function

Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in testis, kidney, bladder and ovary. {ECO:0000269PubMed:14563409}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	55 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003720	telomerase activity
GO:0050220	prostaglandin-E synthase activity
GO:0051082	unfolded protein binding

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0005978	glycogen biosynthetic process
GO:0006278	RNA-dependent DNA replication
GO:0008283	cell proliferation
GO:0042921	glucocorticoid receptor signaling pathway
GO:0043588	skin development
GO:0060430	lung saccule development
GO:0070389	chaperone cofactor-dependent protein refolding