InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tmem57

Summary

InnateDB Protein

IDBP-196566.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tmem57

Protein Name

transmembrane protein 57

Synonyms

1110007C24Rik; 9230118A01Rik; AI317300; AI606104; C61;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030628

InnateDB Gene

IDBG-196564 (Tmem57)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Nucleus membrane {ECO:0000269PubMed:15255972}; Multi-pass membrane protein {ECO:0000269PubMed:15255972}. Cell projection, axon {ECO:0000269PubMed:15255972}. Note=Detected in the nucleus membrane of non-neuronal cells and in axonal outgrowths of neuronal cells.

Disease Associations

Tissue Specificity

Strong expression in whole nervous system up to E12.5. Highly expressed in all neuronal differentiation fields from E14.5 to birth, with highest expression in the telencephalic cortical plate and mitral cells in the olfactory bulb, and lower expression in neuronal progenitor zones. Progressively decreased expression in fields of neuron precursor proliferation from E14.5 and virtually undetectable there by E17.5. No significant expression detected outside the nervous system. After birth, significant expression remains in the cerebellum, olfactory bulb and hippocampus. {ECO:0000269PubMed:15255972}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0007420	brain development
GO:0008150	biological_process

Cellular Component

GO:0005634	nucleus
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0031965	nuclear membrane
GO:0043005	neuron projection
GO:0044306	neuron projection terminus
GO:0045202	synapse