InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myom1

Summary

InnateDB Protein

IDBP-196578.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myom1

Protein Name

myomesin 1

Synonyms

D430047A17Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000072945

InnateDB Gene

IDBG-196576 (Myom1)

Protein Structure

UniProt Annotation

Function

May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. May also contact myosin filaments. Also binds beta-integrins.

Subcellular Localization

Cytoplasm, myofibril, sarcomere, M line {ECO:0000269PubMed:18177667, ECO:0000269PubMed:22562206}.

Disease Associations

Tissue Specificity

Ubiquitously expressed in all striated muscles. Expressed in all fiber types. {ECO:0000269PubMed:18177667}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006936

muscle contraction

Cellular Component

GO:0005856	cytoskeleton
GO:0030017	sarcomere
GO:0031430	M band
GO:0032982	myosin filament

Protein Structure and Domains

PDB ID

MGI:1341430

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set

PFAM

PF00041
PF01108
PF07679

PRINTS

PIRSF

SMART

SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q62234