Version 5.4
Mus musculus Protein: Slco1a1
Summary
InnateDB Protein IDBP-196603.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slco1a1
Protein Name solute carrier organic anion transporter family, member 1a1
Synonyms A530084B21; OATP-1; Oatp1; Oatp1a1; Slc21a1;
Species Mus musculus
Ensembl Protein ENSMUSP00000037022
InnateDB Gene IDBG-196601 (Slco1a1)
Protein Structure
UniProt Annotation
Function Mediates the Na(+)-independent transport of organic anions such as taurocholate, prostaglandin E2 (PGE2), dehydroepiandrosterone sulfate (DHEAS), 17-beta-glucuronosyl estradiol, estrone-3-sulfate, sulfobromophthalein (BSP), ouabain and gadoxetate.
Subcellular Localization Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in liver, and at lower levels in kidney. Not detected in other tissues.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0008514 organic anion transmembrane transporter activity
Biological Process
GO:0006810 transport
GO:0015711 organic anion transport
GO:0033574 response to testosterone
GO:0035634 response to stilbenoid
GO:0055085 transmembrane transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
Protein Structure and Domains
PDB ID MGI:1351891
InterPro IPR002350 Kazal domain
IPR004156 Organic anion transporter polypeptide OATP
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain
PFAM PF00050
PF07648
PF03137
PF07690
PRINTS
PIRSF
SMART SM00280
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QXZ6
PhosphoSite PhosphoSite-Q9QXZ6
TrEMBL Q53ZW9
UniProt Splice Variant
Entrez Gene 28248
UniGene Mm.415972
RefSeq NP_038825
MGI ID
MGI Symbol Slco1a1
OMIM
CCDS CCDS39691
HPRD
IMGT
EMBL AB031813 AF148218 AF223067 AY195868 AY243579 BC041147 CH466572
GenPept AAF19351 AAF31457 AAH41147 AAO45089 AAP42199 BAB12444 EDL10629

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca