InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NSUN5

Summary

InnateDB Protein

IDBP-19667.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NSUN5

Protein Name

NOP2/Sun domain family, member 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000252594

InnateDB Gene

IDBG-19665 (NSUN5)

Protein Structure

UniProt Annotation

Function

S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 in 28S rRNA. {ECO:0000250}.

Subcellular Localization

Disease Associations

Note=NSUN5 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

Tissue Specificity

Ubiquitous. Detected in placenta, heart and skeletal muscle. {ECO:0000269PubMed:11978965, ECO:0000269PubMed:12073013}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008168	methyltransferase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0032259

methylation

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus

Protein Structure and Domains

PDB ID

InterPro

IPR001678 Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p
IPR023267 RNA (C5-cytosine) methyltransferase
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF01189

PRINTS

PR02008

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96P11