InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eif4e

Summary

InnateDB Protein

IDBP-196689.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eif4e

Protein Name

eukaryotic translation initiation factor 4E

Synonyms

EG668879; eIF-4E; Eif4e-ps; If4e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029803

InnateDB Gene

IDBG-196687 (Eif4e)

Protein Structure

UniProt Annotation

Function

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. May play an important role in spermatogenesis through translational regulation of stage- specific mRNAs during germ cell development (By similarity). Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. {ECO:0000250, ECO:0000269PubMed:18805096}.

Subcellular Localization

Cytoplasm, P-body {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:22900038}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	29 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	45 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003743	translation initiation factor activity
GO:0005515	protein binding
GO:0031370	eukaryotic initiation factor 4G binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0006413	translational initiation
GO:0006417	regulation of translation
GO:0030324	lung development
GO:0045087	innate immune response (InnateDB)
GO:0045931	positive regulation of mitotic cell cycle

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005737	cytoplasm
GO:0005845	mRNA cap binding complex
GO:0010494	cytoplasmic stress granule
GO:0016281	eukaryotic translation initiation factor 4F complex
GO:0016442	RISC complex
GO:0033391	chromatoid body
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome