InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Map1lc3b

Summary

InnateDB Protein

IDBP-196692.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Map1lc3b

Protein Name

microtubule-associated protein 1 light chain 3 beta

Synonyms

1010001C15Rik; Atg8; LC3b; Map1lc3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034270

InnateDB Gene

IDBG-196690 (Map1lc3b)

Protein Structure

UniProt Annotation

Function

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes (By similarity). Localizes also to discrete punctae along the ciliary axoneme. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 97 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	97 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0006914	autophagy

Cellular Component

GO:0000421	autophagic vacuole membrane
GO:0005737	cytoplasm
GO:0005776	autophagic vacuole
GO:0005874	microtubule
GO:0005930	axoneme
GO:0012505	endomembrane system
GO:0031410	cytoplasmic vesicle