Version 5.4
Mus musculus Protein: Sh3gl3
Summary
InnateDB Protein IDBP-196719.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sh3gl3
Protein Name SH3-domain GRB2-like 3
Synonyms EEN-B2; Sh3d2c; Sh3d2c2; SH3P13;
Species Mus musculus
Ensembl Protein ENSMUSP00000032874
InnateDB Gene IDBG-196717 (Sh3gl3)
Protein Structure
UniProt Annotation
Function Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Associated with postsynaptic endosomes in hippocampal neurons. Associated with presynaptic endosomes in olfactory neurons (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 42 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0042802 identical protein binding
Biological Process
GO:0006897 endocytosis
Cellular Component
GO:0005737 cytoplasm
GO:0031901 early endosome membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:700011
InterPro IPR001452 SH3 domain
IPR004148 BAR domain
IPR011511 Variant SH3 domain
PFAM PF00018
PF14604
PF03114
PF07653
PRINTS PR00452
PIRSF
SMART SM00326
SM00721
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q62421
PhosphoSite PhosphoSite-Q62421
TrEMBL Q497N4
UniProt Splice Variant
Entrez Gene 20408
UniGene Mm.736
RefSeq NP_001264883
MGI ID
MGI Symbol Sh3gl3
OMIM
CCDS
HPRD
IMGT
EMBL AC139213 AC175489 AC175660 BC027096 BC100453 CAAA01224293 U58887
GenPept AAC72268 AAH27096 AAI00454

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca