Version 5.4
Mus musculus Protein: Chrm5
Summary
InnateDB Protein IDBP-196722.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Chrm5
Protein Name cholinergic receptor, muscarinic 5
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000097185
InnateDB Gene IDBG-196720 (Chrm5)
Protein Structure
UniProt Annotation
Function The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0016907 G-protein coupled acetylcholine receptor activity
GO:0016934 extracellular-glycine-gated chloride channel activity
Biological Process
GO:0001696 gastric acid secretion
GO:0006821 chloride transport
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway
GO:0015872 dopamine transport
GO:0019226 transmission of nerve impulse
GO:0060304 regulation of phosphatidylinositol dephosphorylation
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID MGI:109248
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000502 Muscarinic acetylcholine receptor M5
IPR000995 Muscarinic acetylcholine receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019430 7TM GPCR, serpentine receptor class x (Srx)
PFAM PF00001
PF10328
PRINTS PR00237
PR00542
PR00243
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q920H4
PhosphoSite PhosphoSite-Q920H4
TrEMBL
UniProt Splice Variant
Entrez Gene 213788
UniGene Mm.297624
RefSeq NP_991352
MGI ID
MGI Symbol Chrm5
OMIM
CCDS CCDS16556
HPRD
IMGT
EMBL AF264051 AL731840 BC120615
GenPept AAI20616 AAL26028 CAM25807

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca