InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Iapp

Summary

InnateDB Protein

IDBP-196725.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Iapp

Protein Name

islet amyloid polypeptide

Synonyms

DAP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043956

InnateDB Gene

IDBG-196723 (Iapp)

Protein Structure

UniProt Annotation

Function

Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0042802	identical protein binding

Biological Process

GO:0019233	sensory perception of pain
GO:0031018	endocrine pancreas development
GO:0042755	eating behavior
GO:0045596	negative regulation of cell differentiation
GO:0045779	negative regulation of bone resorption

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005829	cytosol
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:96382

InterPro

IPR000443 Pro-islet amyloid polypeptide
IPR001693 Calcitonin peptide-like
IPR015476 Calcitonin gene-related peptide
IPR021116 Procalcitonin/adrenomedullin

PFAM

PF00214

PRINTS

PR00818
PR00817

PIRSF

SMART

SM00113

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt