InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Recql

Summary

InnateDB Protein

IDBP-196787.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Recql

Protein Name

RecQ protein-like

Synonyms

RecQ1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032370

InnateDB Gene

IDBG-196785 (Recql)

Protein Structure

UniProt Annotation

Function

Isoform alpha is a DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Isoform beta may have important roles in the meiotic process. Both isoforms exhibit a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. {ECO:0000269PubMed:9838113}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform alpha is expressed in all tissues examined. Isoform beta is only expressed in spermatocytes, expression increases at pachytene (17 days old) and decreases after completion of meiosis II (7 weeks old). {ECO:0000269PubMed:9838113}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0004386	helicase activity
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0036310	annealing helicase activity
GO:0043140	ATP-dependent 3'-5' DNA helicase activity

Biological Process

GO:0000733	DNA strand renaturation
GO:0006200	ATP catabolic process
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0032508	DNA duplex unwinding

Cellular Component

GO:0005634	nucleus
GO:0015630	microtubule cytoskeleton

Protein Structure and Domains

PDB ID

MGI:103021

InterPro

IPR001650 Helicase, C-terminal
IPR004589 DNA helicase, ATP-dependent, RecQ type
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR018982 RQC domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270
PF09382

PRINTS

PIRSF

SMART

SM00490
SM00487
SM00956

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Z129