InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ryr3

Summary

InnateDB Protein

IDBP-196810.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ryr3

Protein Name

ryanodine receptor 3

Synonyms

AI851294; C230090H21; RYR-3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000079503

InnateDB Gene

IDBG-196806 (Ryr3)

Protein Structure

UniProt Annotation

Function

Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Plays a role in cellular calcium signaling. Contributes to cellular calcium ion homeostasis. Isoform 2 lacks a predicted transmembrane segment and does not form functional calcium channels by itself; however, it can form tetramers with isoforms that contain the full complement of transmembrane segments and modulate their activity. {ECO:0000269PubMed:11500519, ECO:0000269PubMed:11717163, ECO:0000269PubMed:17596299, ECO:0000269PubMed:7621815, ECO:0000269PubMed:8702664, ECO:0000269PubMed:9582272}.

Subcellular Localization

Sarcoplasmic reticulum membrane {ECO:0000305PubMed:9582272}; Multi-pass membrane protein {ECO:0000305PubMed:9582272}. Membrane {ECO:0000269PubMed:9582272}; Multi-pass membrane protein {ECO:0000269PubMed:9582272}. Microsome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cytoplasmic. {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in hippocampus, cerebellum, striatum, frontal brain cortex and parietal brain cortex. Detected in skeletal muscle, diaphragm muscle and myometrium (at protein level). Detected in egg cells. Detected in heart, diaphragm, stomach, spleen, ovary, testis germ cells, brain and cerebellum. Detected in cerebral artery smooth muscle cells. {ECO:0000269PubMed:11717163, ECO:0000269PubMed:17596299, ECO:0000269PubMed:7621815, ECO:0000269PubMed:7635066, ECO:0000269PubMed:7876312, ECO:0000269PubMed:9582272}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005219	ryanodine-sensitive calcium-release channel activity
GO:0005262	calcium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding

Biological Process

GO:0006811	ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006941	striated muscle contraction
GO:0051289	protein homotetramerization
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0071277	cellular response to calcium ion
GO:0071286	cellular response to magnesium ion
GO:0071313	cellular response to caffeine
GO:0071318	cellular response to ATP

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030314	junctional membrane complex
GO:0033017	sarcoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

MGI:99684

InterPro

IPR000699 RIH (RyR and IP3R Homology) domain
IPR001870 B30.2/SPRY domain
IPR002048 EF-hand domain
IPR003032 Ryanodine receptor Ryr
IPR003877 SPla/RYanodine receptor SPRY
IPR005821 Ion transport domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR009460 Ryanodine Receptor TM 4-6
IPR013333 Ryanodine receptor
IPR013662 RyR/IP3R Homology associated domain
IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptor
IPR016093 MIR motif
IPR018355 SPla/RYanodine receptor subgroup

PFAM