Version 5.4
Mus musculus Protein: Emilin2
Summary
InnateDB Protein IDBP-196833.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Emilin2
Protein Name elastin microfibril interfacer 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000024849
InnateDB Gene IDBG-196831 (Emilin2)
Protein Structure
UniProt Annotation
Function May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity. Major component of the cochlear basilar membrane (BM) which may contribute to the developmental assembly or function of the BM.
Subcellular Localization Secreted, extracellular space, extracellular matrix. Note=Found mainly at the interface between amorphous elastin and microfibrils.
Disease Associations
Tissue Specificity Highest levels are present in cochlea of P8 pups, followed by modest levels in adult heart and lung, and much lower levels in forebrain, brainstem, cerebellum and hypothalamus. Very low levels detected in muscle, liver, kidney and eye.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005581 collagen trimer
Protein Structure and Domains
PDB ID MGI:2389136
InterPro IPR001073 Complement C1q protein
IPR008983 Tumour necrosis factor-like domain
IPR011489 EMI domain
PFAM PF00386
PF07546
PRINTS PR00007
PIRSF
SMART SM00110
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K482
PhosphoSite PhosphoSite-Q8K482
TrEMBL Q3U1J9
UniProt Splice Variant
Entrez Gene 246707
UniGene Mm.416146
RefSeq NP_660140
MGI ID
MGI Symbol Emilin2
OMIM
CCDS CCDS37686
HPRD
IMGT
EMBL AF468645 AK154230 AK155909 AK155913 AK170822 AK170953 AK171015 AK171020 AK171592 BC053753 GQ872460
GenPept AAH53753 AAM53532 ACX47082 BAE32450 BAE33498 BAE33501 BAE42053 BAE42136 BAE42186 BAE42190 BAE42548

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca