Mus musculus Protein: Eftud1 | |||||||||||
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Summary | |||||||||||
InnateDB Protein | IDBP-196872.6 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | Eftud1 | ||||||||||
Protein Name | elongation factor Tu GTP binding domain containing 1 | ||||||||||
Synonyms | 4932434J20Rik; 6030468D11Rik; AI451340; AU019507; AU022896; D7Ertd791e; | ||||||||||
Species | Mus musculus | ||||||||||
Ensembl Protein | ENSMUSP00000046046 | ||||||||||
InnateDB Gene | IDBG-196870 (Eftud1) | ||||||||||
Protein Structure | |||||||||||
UniProt Annotation | |||||||||||
Function | Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits (By similarity). {ECO:0000250}. | ||||||||||
Subcellular Localization | |||||||||||
Disease Associations | |||||||||||
Tissue Specificity | |||||||||||
Comments | |||||||||||
Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||
PDB ID | MGI:2141969 | ||||||||||
InterPro |
IPR000640
Translation elongation factor EFG, V domain IPR000795 Elongation factor, GTP-binding domain IPR004161 Translation elongation factor EFTu/EF1A, domain 2 IPR005225 Small GTP-binding protein domain IPR009000 Translation protein, beta-barrel domain IPR009022 Elongation factor G, III-V domain IPR020568 Ribosomal protein S5 domain 2-type fold IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00679
PF00009 PF03144 PF14492 |
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PRINTS |
PR00315
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PIRSF | |||||||||||
SMART |
SM00838
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TIGRFAMs | |||||||||||
Post-translational Modifications | |||||||||||
Modification | |||||||||||
Cross-References | |||||||||||
SwissProt | Q8C0D5 | ||||||||||
PhosphoSite | PhosphoSite-Q8C0D5 | ||||||||||
TrEMBL | D3Z1V3 | ||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 101592 | ||||||||||
UniGene | Mm.238020 | ||||||||||
RefSeq | NP_780526 | ||||||||||
MGI ID | |||||||||||
MGI Symbol | Eftud1 | ||||||||||
OMIM | |||||||||||
CCDS | CCDS21410 | ||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | AC132142 AC138270 AK028676 AK031647 BC031852 BC045616 | ||||||||||
GenPept | AAH31852 AAH45616 BAC26061 BAC27493 | ||||||||||