Version 5.4
Mus musculus Protein: Spns2
Summary
InnateDB Protein IDBP-196907.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spns2
Protein Name spinster homolog 2 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000044418
InnateDB Gene IDBG-196905 (Spns2)
Protein Structure
UniProt Annotation
Function Sphingolipid transporter required for migration of myocardial precursors. Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0022857 transmembrane transporter activity
GO:0046624 sphingolipid transporter activity
Biological Process
GO:0001782 B cell homeostasis
GO:0002260 lymphocyte homeostasis
GO:0002920 regulation of humoral immune response
GO:0003376 sphingosine-1-phosphate signaling pathway
GO:0006665 sphingolipid metabolic process
GO:0006869 lipid transport
GO:0043029 T cell homeostasis
GO:0048073 regulation of eye pigmentation
GO:0048535 lymph node development
GO:0055085 transmembrane transport
GO:0060348 bone development
GO:0072676 lymphocyte migration
Cellular Component
GO:0005575 cellular_component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2384936
InterPro IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain
PFAM PF00083
PF07690
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91VM4
PhosphoSite PhosphoSite-Q91VM4
TrEMBL
UniProt Splice Variant
Entrez Gene 216892
UniGene Mm.212812
RefSeq NP_694700
MGI ID
MGI Symbol Spns2
OMIM
CCDS CCDS48841
HPRD
IMGT
EMBL AB441166 AL662812 BC011467 BC025823
GenPept AAH11467 AAH25823 BAH15193 CAI52006

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca