InnateDB Protein
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IDBP-196952.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Banp
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Protein Name
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BTG3 associated nuclear protein
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Synonyms
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AA408158; SMAR1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000026354
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InnateDB Gene
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IDBG-196950 (Banp)
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Protein Structure
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Function |
Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest and inhibits tumor growth. {ECO:0000269PubMed:10950932, ECO:0000269PubMed:12494467, ECO:0000269PubMed:15371550, ECO:0000269PubMed:15623522, ECO:0000269PubMed:15701641, ECO:0000269PubMed:16166625, ECO:0000269PubMed:17229733}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:10940556, ECO:0000269PubMed:12494467, ECO:0000269PubMed:15371550, ECO:0000269PubMed:15701641, ECO:0000269PubMed:16166625}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in heart, spleen, and thymus. Isoform 1 is highly expressed in kidney, brain and testis. Isoform 3 is highly expressed in kidney and lung. {ECO:0000269PubMed:10940556, ECO:0000269PubMed:10950932, ECO:0000269PubMed:12494467}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
10 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1889023
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InterPro |
IPR018379
BEN domain
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PFAM |
PF10523
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PRINTS |
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PIRSF |
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SMART |
SM01025
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TIGRFAMs |
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Modification |
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SwissProt |
Q8VBU8
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PhosphoSite |
PhosphoSite-Q8VBU8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
53325
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UniGene |
Mm.411296
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RefSeq |
NP_001272910
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MGI ID |
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MGI Symbol |
Banp
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OMIM |
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CCDS |
CCDS72176
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HPRD |
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IMGT |
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EMBL |
AF091234
AF235503
AK154088
BC013339
BC021650
BC022168
BC062641
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GenPept |
AAC36358
AAG16659
AAH13339
AAH21650
AAH22168
AAH62641
BAE32366
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