Version 5.4
Mus musculus Protein: Apof
Summary
InnateDB Protein IDBP-197023.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Apof
Protein Name apolipoprotein F
Synonyms AI255964;
Species Mus musculus
Ensembl Protein ENSMUSP00000050300
InnateDB Gene IDBG-197021 (Apof)
Protein Structure
UniProt Annotation
Function Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity Liver. {ECO:0000269PubMed:11836406}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0006641 triglyceride metabolic process
GO:0008203 cholesterol metabolic process
GO:0033344 cholesterol efflux
Cellular Component
GO:0005575 cellular_component
GO:0034362 low-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
Protein Structure and Domains
PDB ID MGI:104539
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91V80
PhosphoSite PhosphoSite-Q91V80
TrEMBL
UniProt Splice Variant
Entrez Gene 103161
UniGene Mm.26513
RefSeq NP_598758
MGI ID
MGI Symbol Apof
OMIM
CCDS CCDS24268
HPRD
IMGT
EMBL AF411830 AF411831 AF411832 BC010815 BC022795 BC024769 BC025827
GenPept AAH10815 AAH22795 AAH24769 AAH25827 AAL06339 AAL06340 AAL06341

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca