InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abcc9

Summary

InnateDB Protein

IDBP-197033.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abcc9

Protein Name

ATP-binding cassette, sub-family C (CFTR/MRP), member 9

Synonyms

AI414027; AI449286; Sur2; SUR2A; SUR2B;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000084805

InnateDB Gene

IDBG-197029 (Abcc9)

Protein Structure

UniProt Annotation

Function

Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.

Subcellular Localization

Membrane {ECO:0000255PROSITE- ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255PROSITE-ProRule:PRU00441}.

Disease Associations

Tissue Specificity

Isoforms SUR2A and SUR2B are found in cerebellum, eye, atrium, ventricle, urinary bladder and skeletal muscle. Isoform SUR2B is also found in forebrain, liver, lung, pancreas, kidney, spleen, stomach, small intestine, colon, uterus, ovary and fat tissue. Isoform SUR2C is expressed exclusively in the heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005267	potassium channel activity
GO:0005524	ATP binding
GO:0008281	sulfonylurea receptor activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances
GO:0044325	ion channel binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0007165	signal transduction
GO:0051607	defense response to virus
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016021	integral component of membrane
GO:0030017	sarcomere
GO:0042383	sarcolemma

Protein Structure and Domains

PDB ID

MGI:1352630

InterPro

IPR000388 Sulphonylurea receptor
IPR001140 ABC transporter, transmembrane domain
IPR001475 Sulphonylurea receptor, type 2
IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR011527 ABC transporter type 1, transmembrane domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00664
PF13748
PF00005

PRINTS

PR01092
PR01094

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt