InnateDB Protein
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IDBP-197077.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Zfpm1
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Protein Name
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zinc finger protein, multitype 1
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Synonyms
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FOG; Fog1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000058037
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InnateDB Gene
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IDBG-197075 (Zfpm1)
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Protein Structure
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Function |
Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2. {ECO:0000269PubMed:10078204, ECO:0000269PubMed:10329627, ECO:0000269PubMed:11940669, ECO:0000269PubMed:12356738, ECO:0000269PubMed:14614148, ECO:0000269PubMed:9230307, ECO:0000269PubMed:9553047}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:9230307}.
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Disease Associations |
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Tissue Specificity |
Mainly expressed in hematopoietic tissues. Expressed in the spleen, a primary site of hematopoiesis in the adult mouse, as well as in the liver and testis, but not in the heart, brain, lung, kidney, or skeletal muscle. Among hematopoietic cell lines, it is strongly expressed in erythroid and megakaryocytic cell lines. Expressed at low level in several lymphoid and early myeloid cell lines. Not expressed in mast cell and macrophage lines. Expressed in the heart, where it colocalizes with GATA4, GATA5 and GATA6. {ECO:0000269PubMed:14614148, ECO:0000269PubMed:9230307}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated |
Total |
22
[view]
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Protein-Protein |
18
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
Accession |
GO Term |
GO:0001078
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
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GO:0001085
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RNA polymerase II transcription factor binding
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GO:0001102
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RNA polymerase II activating transcription factor binding
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GO:0003677
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DNA binding
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GO:0003714
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transcription corepressor activity
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GO:0005515
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protein binding
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GO:0008134
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transcription factor binding
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GO:0046872
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metal ion binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1095400
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InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
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PFAM |
PF00096
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PRINTS |
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PIRSF |
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SMART |
SM00355
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TIGRFAMs |
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Modification |
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SwissProt |
O35615
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PhosphoSite |
PhosphoSite-O35615
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
22761
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UniGene |
Mm.390068
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RefSeq |
NP_033595
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MGI ID |
1SRK
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MGI Symbol |
Zfpm1
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OMIM |
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CCDS |
CCDS22733
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HPRD |
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IMGT |
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EMBL |
AF006492
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GenPept |
AAC53292
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