InnateDB Protein
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IDBP-197083.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Uchl5
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Protein Name
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ubiquitin carboxyl-terminal esterase L5
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Synonyms
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5830413B11Rik; Uch37;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000018333
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InnateDB Gene
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IDBG-197081 (Uchl5)
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Protein Structure
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Function |
Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 156 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
156 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1914848
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InterPro |
IPR001578
Peptidase C12, ubiquitin carboxyl-terminal hydrolase
IPR017390
Ubiquitinyl hydrolase, UCH37 type
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PFAM |
PF01088
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PRINTS |
PR00707
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PIRSF |
PIRSF038120
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9WUP7
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PhosphoSite |
PhosphoSite-Q9WUP7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
56207
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UniGene |
Mm.401752
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RefSeq |
NP_001153338
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MGI ID |
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MGI Symbol |
Uchl5
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AF148447
AF175903
AK007860
AK011117
AK017925
BC006891
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GenPept |
AAD31534
AAD50311
AAH06891
BAB25312
BAB27412
BAB31005
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