Version 5.4
Mus musculus Protein: Fmn1
Summary
InnateDB Protein IDBP-197161.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fmn1
Protein Name formin 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000099606
InnateDB Gene IDBG-197159 (Fmn1)
Protein Structure
UniProt Annotation
Function Plays a role in the formation of adherens junction and the polymerization of linear actin cables. {ECO:0000269PubMed:14647292, ECO:0000269PubMed:15198975}.
Subcellular Localization Nucleus. Cytoplasm. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localization to the adherens junctions is alpha- catenin-dependent. Also localizes to F-actin bundles originating from adherens junctions.Isoform 2: Cytoplasm, cytoskeleton. Note=Isoform 2 localizes to microtubules.
Disease Associations
Tissue Specificity It is present in the adult kidney, testis, limb, ovary, brain, small intestine, salivary gland and harderian gland. Isoforms 1, 2 and 5 are detected in skin and keratinocytes. Isoform 5 is found throughout the embryo. {ECO:0000269PubMed:14647292, ECO:0000269PubMed:2392150}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0017124 SH3 domain binding
Biological Process
GO:0001822 kidney development
GO:0010467 gene expression
GO:0030838 positive regulation of actin filament polymerization
GO:0035136 forelimb morphogenesis
GO:0035137 hindlimb morphogenesis
GO:0045010 actin nucleation
GO:0048705 skeletal system morphogenesis
GO:0048813 dendrite morphogenesis
GO:0051127 positive regulation of actin nucleation
GO:0051894 positive regulation of focal adhesion assembly
GO:0060173 limb development
GO:0072092 ureteric bud invasion
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0015630 microtubule cytoskeleton
Protein Structure and Domains
PDB ID MGI:101815
InterPro IPR001265 Formin homology family, Cappuccino subfamily
IPR015425 Formin, FH2 domain
PFAM PF02181
PRINTS PR00828
PIRSF
SMART SM00498
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q05860
PhosphoSite PhosphoSite-Q05860
TrEMBL
UniProt Splice Variant
Entrez Gene 14260
UniGene
RefSeq NP_034360
MGI ID 2RM0
MGI Symbol Fmn1
OMIM
CCDS CCDS16559
HPRD
IMGT
EMBL AL672253 AL691437 AL691466 X53599 X62379
GenPept CAA37668 CAA44244 CAM14988 CAM14989 CAM18143 CAM18583 CAM18585

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca