InnateDB Protein
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IDBP-197165.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Fmn1
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Protein Name
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formin 1
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000080093
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InnateDB Gene
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IDBG-197159 (Fmn1)
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Protein Structure
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Function |
Plays a role in the formation of adherens junction and the polymerization of linear actin cables. {ECO:0000269PubMed:14647292, ECO:0000269PubMed:15198975}.
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Subcellular Localization |
Nucleus. Cytoplasm. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localization to the adherens junctions is alpha- catenin-dependent. Also localizes to F-actin bundles originating from adherens junctions.Isoform 2: Cytoplasm, cytoskeleton. Note=Isoform 2 localizes to microtubules.
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Disease Associations |
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Tissue Specificity |
It is present in the adult kidney, testis, limb, ovary, brain, small intestine, salivary gland and harderian gland. Isoforms 1, 2 and 5 are detected in skin and keratinocytes. Isoform 5 is found throughout the embryo. {ECO:0000269PubMed:14647292, ECO:0000269PubMed:2392150}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001265
Formin homology family, Cappuccino subfamily
IPR015425
Formin, FH2 domain
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PFAM |
PF02181
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PRINTS |
PR00828
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PIRSF |
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SMART |
SM00498
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TIGRFAMs |
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Modification |
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SwissProt |
Q05860
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PhosphoSite |
PhosphoSite-Q05860
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
14260
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UniGene |
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RefSeq |
NP_001274746
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MGI ID |
2RM0
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MGI Symbol |
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OMIM |
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CCDS |
CCDS71113
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HPRD |
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IMGT |
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EMBL |
AL672253
AL691437
AL691466
X53599
X62379
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GenPept |
CAA37668
CAA44244
CAM14988
CAM14989
CAM18143
CAM18583
CAM18585
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