Version 5.4
Mus musculus Protein: Mesdc2
Summary
InnateDB Protein IDBP-197183.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mesdc2
Protein Name mesoderm development candidate 2
Synonyms 2210015O11Rik; AW537813; mesd; mKIAA0081; msd;
Species Mus musculus
Ensembl Protein ENSMUSP00000091768
InnateDB Gene IDBG-197181 (Mesdc2)
Protein Structure
UniProt Annotation
Function Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. {ECO:0000269PubMed:12581525, ECO:0000269PubMed:21397183}.
Subcellular Localization Endoplasmic reticulum {ECO:0000269PubMed:12581525}.
Disease Associations
Tissue Specificity Expressed in many tissues, but not in skeletal muscles. {ECO:0000269PubMed:11247670}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0050750 low-density lipoprotein particle receptor binding
Biological Process
GO:0006457 protein folding
GO:0007498 mesoderm development
GO:0016055 Wnt signaling pathway
GO:0034394 protein localization to cell surface
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:1891421
InterPro IPR019330 Mesoderm development candidate 2
PFAM PF10185
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9ERE7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 67943
UniGene Mm.400296
RefSeq NP_075892
MGI ID 3OFH
MGI Symbol Mesdc2
OMIM
CCDS CCDS21415
HPRD
IMGT
EMBL AF311213 AK008735 AK031949 AK076760 AK076773 BC014742
GenPept AAG33621 AAH14742 BAB25865 BAC27617 BAC36471 BAC36476

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca