InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rgs18

Summary

InnateDB Protein

IDBP-197199.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rgs18

Protein Name

regulator of G-protein signaling 18

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027603

InnateDB Gene

IDBG-197197 (Rgs18)

Protein Structure

UniProt Annotation

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha- 2, G(i) alpha-3 and G(q) alpha.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Expressed in bone marrow, spleen, fetal liver and lung. At very low levels expressed in heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity