InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Scg5

Summary

InnateDB Protein

IDBP-197223.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scg5

Protein Name

secretogranin V

Synonyms

7B2; AI325031; Sgne-1; Sgne1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024005

InnateDB Gene

IDBG-197221 (Scg5)

Protein Structure

UniProt Annotation

Function

Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. {ECO:0000269PubMed:10089884, ECO:0000269PubMed:9348280}.

Subcellular Localization

Secreted. Note=Neuroendocrine and endocrine secretory granules.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0005515	protein binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0007218	neuropeptide signaling pathway
GO:0016486	peptide hormone processing
GO:0043086	negative regulation of catalytic activity
GO:0046883	regulation of hormone secretion