InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cmas

Summary

InnateDB Protein

IDBP-197229.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cmas

Protein Name

cytidine monophospho-N-acetylneuraminic acid synthetase

Synonyms

AW208911; CMPNeu5Ac; D6Bwg0250e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032419

InnateDB Gene

IDBG-197227 (Cmas)

Protein Structure

UniProt Annotation

Function

Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). {ECO:0000269PubMed:9689047}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11893746, ECO:0000269PubMed:9689047}.

Disease Associations

Tissue Specificity

Highly expressed in brain and heart, and at intermediate level muscle and liver. {ECO:0000269PubMed:9689047}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008781	N-acylneuraminate cytidylyltransferase activity

Biological Process

GO:0006054	N-acetylneuraminate metabolic process
GO:0006055	CMP-N-acetylneuraminate biosynthetic process
GO:0009103	lipopolysaccharide biosynthetic process