Version 5.4
Mus musculus Protein: St8sia1
Summary
InnateDB Protein IDBP-197282.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol St8sia1
Protein Name ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
Synonyms 9330109E03Rik; GD3S; Sia-T; Siat8; Siat8a;
Species Mus musculus
Ensembl Protein ENSMUSP00000032421
InnateDB Gene IDBG-197280 (St8sia1)
Protein Structure
UniProt Annotation
Function Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid. {ECO:0000269PubMed:8910600}.
Subcellular Localization Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
GO:0008373 sialyltransferase activity
Biological Process
GO:0006486 protein glycosylation
GO:0006665 sphingolipid metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0034605 cellular response to heat
GO:0097503 sialylation
Cellular Component
GO:0030173 integral component of Golgi membrane
Protein Structure and Domains
PDB ID MGI:106011
InterPro IPR001675 Glycosyl transferase, family 29
IPR012163 Sialyltransferase
PFAM PF00777
PRINTS
PIRSF PIRSF005557
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q64687
PhosphoSite PhosphoSite-
TrEMBL Q9EPK0
UniProt Splice Variant
Entrez Gene 20449
UniGene Mm.454279
RefSeq NP_035504
MGI ID
MGI Symbol St8sia1
OMIM
CCDS CCDS20689
HPRD
IMGT
EMBL AJ401102 AK042207 BC024821 CH466572 X84235
GenPept AAH24821 BAE20627 CAA59014 CAC20706 EDL10653

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca