Version 5.4
Mus musculus Protein: Mvd
Summary
InnateDB Protein IDBP-197306.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mvd
Protein Name mevalonate (diphospho) decarboxylase
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000006692
InnateDB Gene IDBG-197304 (Mvd)
Protein Structure
UniProt Annotation
Function Performs the first committed step in the biosynthesis of isoprenes.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004163 diphosphomevalonate decarboxylase activity
GO:0005524 ATP binding
GO:0030544 Hsp70 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0008284 positive regulation of cell proliferation
GO:0008299 isoprenoid biosynthetic process
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:2179327
InterPro IPR005935 Diphosphomevalonate decarboxylase
IPR006204 GHMP kinase N-terminal domain
IPR013750 GHMP kinase, C-terminal domain
IPR020568 Ribosomal protein S5 domain 2-type fold
PFAM PF00288
PF08544
PRINTS
PIRSF PIRSF015950
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99JF5
PhosphoSite PhosphoSite-Q99JF5
TrEMBL Q3UYC1
UniProt Splice Variant
Entrez Gene 192156
UniGene
RefSeq NP_619597
MGI ID 3F0N
MGI Symbol Mvd
OMIM
CCDS CCDS22738
HPRD
IMGT
EMBL AJ309922 AK089354 AK134803 AK154883 AK170773 BC008526 CH466525
GenPept AAH08526 BAC40852 BAE22291 BAE32901 BAE42019 CAC35731 EDL11681

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca