InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Actc1

Summary

InnateDB Protein

IDBP-197314.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Actc1

Protein Name

actin, alpha, cardiac muscle 1

Synonyms

Actc-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000087736

InnateDB Gene

IDBG-197312 (Actc1)

Protein Structure

UniProt Annotation

Function

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Subcellular Localization

Cytoplasm, cytoskeleton.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017022	myosin binding

Biological Process

GO:0006200	ATP catabolic process
GO:0030048	actin filament-based movement
GO:0030240	skeletal muscle thin filament assembly
GO:0031032	actomyosin structure organization
GO:0033275	actin-myosin filament sliding
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0045471	response to ethanol
GO:0055003	cardiac myofibril assembly
GO:0055008	cardiac muscle tissue morphogenesis
GO:0060047	heart contraction
GO:0060048	cardiac muscle contraction
GO:0070252	actin-mediated cell contraction

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005884	actin filament
GO:0016020	membrane
GO:0030017	sarcomere
GO:0031674	I band
GO:0042643	actomyosin, actin part
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle